Physiological Determinants of Lower Esophageal Sphincter Function
نویسندگان
چکیده
منابع مشابه
Gastric mechanosensory and lower esophageal sphincter function in rumination syndrome.
Our hypothesis was that rumination syndrome is associated with gastric sensory and motor dysfunction. We studied gastric and somatic sensitivity, reflex relaxation of the lower esophageal sphincter (LES), and gastric compliance and accommodation postprandially and postglucagon. A barostatically controlled gastric bag and esophageal manometry were used to compare gastric sensorimotor functions a...
متن کاملMechanics of sphincter action. Studies on the lower esophageal sphincter.
The purpose of this study was to evaluate the mechanical factors involved in the genesis of lower esophageal sphincter pressure. We determined the relationship between intraluminal pressure and inside diameter, estimated the ratio between the wall thickness to inside radius, and calculated the tension in the wall of the lower esophageal sphincter as a function of the inside diameter. Various de...
متن کاملPharmacologic identification of the lower esophageal sphincter.
The distal 2/3 of the opossum esophagus contains only smooth muscle. Manometry shows that the most distal 1-2 cm is the lower esophageal sphincter. We used a variety of agonists to seek differences between circular muscle from the sphincteric segment and more rostral levels. Isometric contractions of strips from the distal 6 cm were recorded in vitro in response to acetylcholine, carbachol, met...
متن کاملPathophysiology of GERD: Lower Esophageal Sphincter Defects
44 INTRODUCTION T he most common cause of gastroesophageal reflux disease (GERD) is lower esophageal sphincter (LES) dysfunction. The LES is a 3–4 cm high-pressure zone of muscular activity in the distal esophagus. The LES is anatomically and histologically distinct from the esophageal body. Manometric and radiographic studies can be used to identify the LES. Intraluminal manometry can detect t...
متن کاملOutcomes of esophageal surgery, especially of the lower esophageal sphincter.
This paper includes commentaries on outcomes of esophageal surgery, including the mechanisms by which fundoduplication improves lower esophageal sphincter (LES) pressure; the efficacy of the Linx™ management system in improving LES function; the utility of radiologic characterization of antireflux valves following surgery; the correlation between endoscopic findings and reported symptoms follow...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology
سال: 1971
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)33624-8